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Methyl 3-oxo-2-phenylbutyrate Benzeneacetic acid CAS NO: 16648-44-5
Time£ļ2018-12-24 10:31:46°°Page view£ļ1368

Colorless flaky crystals of phenylacetic acid. Easily soluble in hot water, the saturated aqueous solution is 0.131mol / L at 25 °ś. The solubility at 25 °„ C is 4.422 mol / L of chloroform, 1.842 mol / L of carbon tetrachloride, 3.299 mol / L of trichloroethylene, 1.558 mol / L of tetrachloroethylene, and 3.252 mol / L of pentachloroethane. Soluble in ethanol and ether, slightly soluble in cold water. Relative density 1.091. Melting point is 76.5 °„ C. The boiling point is 265.5 °„ C. Irritating. For organic synthesis. Make spices. Plant growth stimulating hormone.
Chinese name
Phenylacetic acid

Foreign name
Phenylacetic acid

Aliases
¶Ń-Toluic acid, phenylacetic acid

Molecular formula
C8H8O2
Molecular weight: 136.15
CAS; 16648-44-5
Content: 99%
Relative molecular mass
136.15
Melting point (°„ C): 76.5
Relative density (water = 1): 1.09 (77 °„ C)
Boiling point (°„ C): 265.5
Solubility: slightly soluble in water, soluble in ethanol, ether and ammonia.
Can be oxidized to benzoic acid, can also be oxidized to benzaldehyde, formic acid and carbon dioxide by manganese dioxide and dilute sulfuric acid. Substitution reactions can occur, such as nitration and halogenation.
52.6 kg of 70% sulfuric acid was added to the reaction pot, stirred and heated to about 100 °„ C., 40 kg was dropped within 1 h, and the temperature was raised to 130 °„ C., and the reaction was continued for 2 h. Then 8 kg of water was added to dilute the ammonium bisulfate produced by the reaction, and the layers were allowed to stand. The ammonium bisulfate mother liquor was separated and dehydrated under reduced pressure at 120-130 °„ C for 1 h to obtain phenylacetic acid with a purity of 96-97%. The yield was 95-97. %. Reflux at 100-104 °„ C for 6h, until the oily liquid decreases, cool to 5 °„ C, add hydrochloric acid to adjust the pH to 1-2, shake off, wash the filter cake with water, and dry at 40 °„ C to obtain phenylacetic acid.
Phenylacetic acid is an auxin mainly found in fruits. Low concentration of phenylacetic acid has a honey-like odor and can also be used as an additive in perfumes and as a raw material for the synthesis of penicillin G.
It is used to improve the total yield of penicillin G in the production process of penicillin, and is used as a raw material for formulating spices, pesticides and plant growth regulators. It is also an important organic chemical raw material. Phenylacetic acid has the typical reaction of carboxyl, methylene hydrogen and benzene rings, and generates many useful intermediates. It has a wide range of uses in the pharmaceutical, pesticide, and perfume industries.

 
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